Call for great translational bioinformatics papers 3/08-3/09


I have agreed once again to give a talk at the AMIA Summit on Translational Bioinformatics ) on the “year in review” highlighting some of the most important papers in our field of translational bioinformatics.  Last year’s talk is online.

I am writing to request that you nominate papers that you think are important for me to include from the last 12-15 months.  Nominations of your own papers are fine, but much less compelling than nominations of others’ papers (you can collude though…).   Here are the criteria:

  • I define translational bioinformatics broadly, but expect it to involve molecular-level (genes, small molecules) data AND clinical-level data (diseases, symptoms, drugs)
  • I define bioinformatics as the creation and application of novel methods of analysis/discovery

I have been trolling the sites myself, but want to make sure I ask colleagues in bioinformatics for their thoughts.

I would like to highlight papers that have done a good, creative job at the above, and have a chance to become “classics” over the next 10-20 years.   I expect to discuss about ~15 papers in “1-2 slide” detail and then to have another list of 10 “noteworthy but not discussed in detail” papers.

I would like these nominations by 5 PM on 3/11.  Thanks for your help.  If you don’t want to post publically, you can send to me by email at



  1. I would recommend two papers that use bioinformatics to suggest improvements in cancer diagnosis and cancer prognosis.
    Discovery of DNA methylation markers in cervical cancer using relaxation ranking by Ongenaert et al. BMC Medical Genomics 1:57
    Genomic variation in myeloma: design, content, and initial application of the Bank On A Cure SNP Panel to detect associations with progression-free survival
    Van Ness et al. BMC Medicine 1:57

    The second paper has an associated commentary

    Although these are not self-cites, I do work for the publisher.

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